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Kentaro Miyake Selected Research

Methionine (L-Methionine)

4/2022Linkage of methionine addiction, histone lysine hypermethylation, and malignancy.
1/2022Extent and Instability of Trimethylation of Histone H3 Lysine Increases With Degree of Malignancy and Methionine Addiction.
2/2021Reversion from Methionine Addiction to Methionine Independence Results in Loss of Tumorigenic Potential of Highly-malignant Lung-cancer Cells.
12/2020Histone methylation status of H3K4me3 and H3K9me3 under methionine restriction is unstable in methionine-addicted cancer cells, but stable in normal cells.
11/2020Oral recombinant methioninase increases TRAIL receptor-2 expression to regress pancreatic cancer in combination with agonist tigatuzumab in an orthotopic mouse model.
1/2020Combination of oral recombinant methioninase and decitabine arrests a chemotherapy-resistant undifferentiated soft-tissue sarcoma patient-derived orthotopic xenograft mouse model.
10/2018Oral Recombinant Methioninase Combined with Caffeine and Doxorubicin Induced Regression of a Doxorubicin-resistant Synovial Sarcoma in a PDOX Mouse Model.
2/2018Intra-tumor L-methionine level highly correlates with tumor size in both pancreatic cancer and melanoma patient-derived orthotopic xenograft (PDOX) nude-mouse models.
1/2018Recombinant methioninase (rMETase) is an effective therapeutic for BRAF-V600E-negative as well as -positive melanoma in patient-derived orthotopic xenograft (PDOX) mouse models.
1/2018Targeting altered cancer methionine metabolism with recombinant methioninase (rMETase) overcomes partial gemcitabine-resistance and regresses a patient-derived orthotopic xenograft (PDOX) nude mouse model of pancreatic cancer.
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Kentaro Miyake Research Topics

Disease

78Neoplasms (Cancer)
04/2022 - 01/2017
18Sarcoma (Soft Tissue Sarcoma)
01/2020 - 01/2017
17Neoplasm Metastasis (Metastasis)
02/2022 - 05/2017
15Pancreatic Neoplasms (Pancreatic Cancer)
02/2022 - 05/2017
15Osteosarcoma (Osteogenic Sarcoma)
07/2021 - 01/2017
7Liposarcoma
07/2020 - 01/2018
7Ewing Sarcoma (Sarcoma, Ewing)
05/2019 - 05/2017
6Melanoma (Melanoma, Malignant)
11/2020 - 10/2017
4Adenocarcinoma
02/2021 - 05/2017
4Colonic Neoplasms (Colon Cancer)
12/2020 - 07/2019
3Lymphatic Metastasis
07/2022 - 02/2022
3Necrosis
07/2021 - 09/2019
3Breast Neoplasms (Breast Cancer)
05/2020 - 02/2019
3Synovial Sarcoma (Synovioma)
06/2019 - 04/2018
2Cholangiocarcinoma
07/2022 - 08/2021
2Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
05/2020 - 04/2019
2Leiomyosarcoma
01/2019 - 01/2019
2Uterine Cervical Neoplasms (Cancer of the Cervix)
01/2019 - 01/2017
2Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor)
06/2018 - 01/2018
1Inflammation (Inflammations)
07/2022
1Klatskin Tumor
04/2022
1Primitive Neuroectodermal Tumors (PNET)
12/2021
1Neuroendocrine Tumors (Neuroendocrine Tumor)
12/2021
1Anaphylaxis (Anaphylactic Shock)
10/2021
1Biliary Tract Neoplasms (Biliary Tract Cancer)
08/2021
1Margins of Excision
08/2021
1Lung Neoplasms (Lung Cancer)
02/2021
1Urinary Bladder Neoplasms (Bladder Cancer)
11/2020
1Hemorrhage
05/2020
1Brain Neoplasms (Brain Tumor)
05/2020
1Rhabdomyosarcoma
02/2020
1Malnutrition (Nutritional Deficiencies)
12/2019

Drug/Important Bio-Agent (IBA)

32Doxorubicin (Adriamycin)FDA LinkGeneric
07/2021 - 06/2017
23L-methionine gamma-lyaseIBA
01/2022 - 01/2017
16Methionine (L-Methionine)FDA Link
04/2022 - 01/2017
14GemcitabineFDA Link
04/2022 - 11/2017
13Pharmaceutical PreparationsIBA
10/2021 - 05/2017
11Temozolomide (Temodar)FDA LinkGeneric
07/2020 - 09/2017
8pazopanibFDA Link
07/2020 - 01/2017
7Docetaxel (Taxotere)FDA Link
07/2020 - 11/2017
6palbociclibIBA
07/2021 - 01/2018
5Red Fluorescent ProteinIBA
02/2022 - 05/2017
5Green Fluorescent ProteinsIBA
02/2021 - 05/2017
5eribulinFDA Link
07/2020 - 01/2018
5TrabectedinIBA
07/2020 - 09/2017
5olaratumabIBA
09/2019 - 01/2019
4Irinotecan (Camptosar)FDA LinkGeneric
05/2019 - 11/2017
4130-nm albumin-bound paclitaxelIBA
03/2019 - 01/2017
3Histones (Histone)IBA
04/2022 - 12/2020
3regorafenibIBA
11/2020 - 01/2018
3Proteins (Proteins, Gene)FDA Link
11/2020 - 12/2017
3Caffeine (No Doz)FDA LinkGeneric
02/2020 - 10/2018
2Lysine (L-Lysine)FDA Link
04/2022 - 01/2022
2Paclitaxel (Taxol)FDA LinkGeneric
10/2021 - 05/2020
2EverolimusFDA Link
07/2021 - 09/2019
2Cyclin-Dependent Kinase 4IBA
07/2021 - 11/2017
2AntigensIBA
02/2021 - 11/2020
2Fluorouracil (Carac)FDA LinkGeneric
11/2020 - 09/2019
2Drug CombinationsIBA
11/2020 - 09/2019
2osimertinibIBA
05/2020 - 04/2019
2ErbB Receptors (EGF Receptor)IBA
05/2020 - 04/2019
2Tyrosine Kinase InhibitorsIBA
05/2020 - 04/2019
2Sunitinib (Sutent)FDA Link
09/2019 - 01/2018
2Sorafenib (BAY 43-9006)FDA Link
09/2019 - 08/2019
2Fluorescent Dyes (Fluorescent Probes)IBA
12/2018 - 04/2018
2Imatinib Mesylate (Gleevec)FDA Link
06/2018 - 01/2018
2LyasesIBA
01/2018 - 01/2017
1Hemoglobins (Hemoglobin)IBA
07/2022
1BismuthIBA
04/2022
1Carboplatin (JM8)FDA LinkGeneric
10/2021
1BilirubinIBA
08/2021
1TOR Serine-Threonine KinasesIBA
07/2021
1MTOR InhibitorsIBA
07/2021
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2021
1histone H3 trimethyl Lys4IBA
12/2020
1PlasticsIBA
12/2020
1LigandsIBA
11/2020
1tigatuzumabIBA
11/2020
1Bevacizumab (Avastin)FDA Link
05/2020
1Erlotinib Hydrochloride (CP 358,774)FDA Link
05/2020
1Vinorelbine (Navelbine)FDA LinkGeneric
05/2020
1olaparibIBA
05/2020
1Valproic Acid (Depakote)FDA LinkGeneric
02/2020
1Cyclophosphamide (Cytoxan)FDA LinkGeneric
02/2020
1DecitabineFDA Link
01/2020
1Pioglitazone (Actos)FDA Link
10/2019
1Messenger RNA (mRNA)IBA
10/2019

Therapy/Procedure

48Therapeutics
02/2022 - 01/2017
18Drug Therapy (Chemotherapy)
07/2022 - 11/2017
6Aftercare (After-Treatment)
05/2020 - 01/2017
5Neoadjuvant Therapy
04/2022 - 09/2017
3Oral Administration
06/2018 - 01/2018
2Absorbable Gelatin Sponge
01/2021 - 12/2020
2Pancreaticoduodenectomy
05/2020 - 12/2019
2Laparotomy
06/2018 - 01/2018
2Immunotherapy
09/2017 - 06/2017
1Radiotherapy
07/2022
1Pancreatectomy
12/2021
1Pancreaticojejunostomy
05/2020
1Gastric Bypass (Roux-en-Y Gastric Bypass)
05/2020